The first Global Conference on Air Pollution and Health will be held from October 30 to November 1, 2018, at the World Health Organization’s Headquarters in Geneva, Switzerland. This event was organized in collaboration with the Climate and Clean Air Coalition to Reduce Short-Lived Climate Pollutants (CCAC), Secretariat of the UN Framework Convention on Climate Change (UNFCCC), United Nations Economic Commission for Europe (UNECE), and United Nations Environment, and World Meteorological Organization (WMO). Using the theme, “Improving Air Quality, Combating Climate Change – Saving Lives”, this meeting provides an opportunity for representatives from national governments, intergovernmental agencies, academic universities, research institutions, and civil society, to discuss global health challenges related to air pollution. The first two days will incorporate meetings to discuss scientific evidence about air pollution, identify challenges, and propose strategies to mitigate negative effects on human and environmental health. The third day will include meetings to facilitate discussion on achieving related Sustainable Development Goals, suggest approaches to further engage national health systems, and encourage sustainable political commitment by national governments and other stakeholders.